Nsonaazụ nke nnyocha ọhụrụ e bipụtara na magazin Biomed Central BMC gosiri na turmeric wepụ dị irè dị ka paracetamol na ibelata mgbu na mgbaàmà ndị ọzọ nke ikpere osteoarthritis (OA). Ọmụmụ ihe ahụ gosipụtara na ogige bioavailable dị irè karị n'ibelata mbufụt.
Osteoarthritis bụ ọrịa na-emebi emebi nke nkwonkwo akwara bụ nke a na-eji nbibi nke cartilage, mkpuchi nkwonkwo, ligaments na ọkpụkpụ dị n'okpuru. Ihe ngosi a na-ahụkarị nke osteoarthritis bụ isi ike na mgbu.
N'ịbụ onye Shuba Singhal, PhD na-eduzi, a na-eduzi ọmụmụ ihe ọmụmụ ụlọ ọgwụ na-achịkwa na Ngalaba Orthopedics nke Lok Nayak Jai Prakash Hospital/Maulana Azad Medical College, New Delhi. Maka ọmụmụ ihe ahụ, ndị ọrịa 193 chọpụtara na osteoarthritis nke ikpere bụ ndị a na-ahapụrụ iji nweta ma ọ bụ turmeric wepụ (BCM-95) dị ka capsule 500 mg ugboro abụọ kwa ụbọchị, ma ọ bụ 650 mg mbadamba paracetamol ugboro atọ kwa ụbọchị maka izu isii.
A na-enyocha ihe mgbaàmà ogbu na nkwonkwo ikpere nke mgbu, nkwonkwo nkwonkwo, na mbelata ọrụ anụ ahụ site na iji Western Ontario na McMaster Universities Osteoarthritis Index (WOMAC). Mgbe izu isii nke ọgwụgwọ gasịrị, nyocha nke onye nzaghachi gosipụtara mmụba dị ukwuu na akara WOMAC n'ofe mpaghara niile dị ka otu paracetamol, yana 18% nke ndị otu BCM-95 na-ekwupụta nkwalite 50%, yana 3% nke isiokwu na-achọpụta mmụba 70%.
Nsonaazụ ndị a gosipụtara nke ọma na ihe nrịbama serum nke BCM-95: A na-ebelata ọkwa CRP site na 37.21%, ma belata ọkwa TNF-α site na 74.81%, na-egosi BCM-95 rụrụ nke ọma karịa paracetamol.
Ọmụmụ ihe a bụ ihe na-esochi ọmụmụ ihe Arjuna mere ihe karịrị otu afọ gara aga nke gosipụtara njikọ dị mma n'etiti usoro curcumin flagship ya na nlekọta osteoarthritic.
"Ebumnuche nke ọmụmụ ihe ugbu a bụ iji wulite na ọmụmụ ihe mbụ iji nye nkọwa doro anya na nkọwapụta nke ọma site n'itinye ihe nrịbama na usoro akara ka mma," ka Benny Antony, onye na-ahụ maka nkwonkwo maka Arjuna kwuru. "Mmetụta mgbochi ogbu na nkwonkwo nke BCM-95 na ọrịa ogbu na nkwonkwo bụ nke a na-ekwu na ike ya iji gbanwee ihe nrịbama mgbochi mkpali TNF na CRP."
Knee OA bụ isi ihe kpatara nkwarụ na mgbu n'etiti ndị okenye na ndị agadi. Ihe dị ka 10 ruo 15% nke ndị okenye niile torola agadi karịa afọ 60 nwere ogo ogo OA, yana oke n'etiti ụmụ nwanyị karịa ụmụ nwoke.
"Ọmụmụ ihe a na-ekwughachi mmetụta mgbochi ogbu na nkwonkwo nke BCM-95 ma na-enye olileanya ọhụrụ maka ọtụtụ nde mmadụ imeziwanye ndụ ha," ka Nipen Lavingia, onye ndụmọdụ ọhụụ maka Arjuna Natural nke dabeere na Dallas, TX kwuru.
"Anyị na-amụtakwu banyere usoro dị n'azụ curcumin's mgbochi mkpali mmetụta nke anyị kwenyere na ọ bụ n'ihi ike ya igbochi ihe mgbaàmà pro-inflammatory, dị ka prostaglandins, leukotrienes, na cyclooxygenase-2. Na mgbakwunye, e gosipụtara curcumin iji gbochie ọtụtụ cytokines pro-inflammatory na ndị ogbugbo nke ntọhapụ ha, dị ka tumor necrosis factor-α (TNF-α), IL-1, IL-8, na nitric oxide synthase, "ka Antony kwuru.
Ngwakọta pụrụ iche nke BCM-95 nke curcuminoids na akụrụngwa mmanụ bara ụba nke turmerone na-emeri ihe mgbochi njirimara curcumin nke bioavailability n'ihi ọdịdị lipophilic ya dị elu.
Oge nzipu: Eprel-12-2021